Evaluation of Antihypertensive Drug Use in Chronic Kidney Failure Patients on Hemodialysis at RSUD A.M. Parikesit Tenggarong
Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Ginjal Kronis dengan Hemodialisis di RSUD A.M. Parikesit Tenggarong
DOI:
https://doi.org/10.70392/jrn.v2i1.2132Keywords:
Chronic kidney diseases, Hemodialysis, Outpatient, AntihypertensiveAbstract
Hypertension is common in patients with chronic kidney disease on hemodialysis and can be the main cause of death, so antihypertensive drugs are needed. Accurate antihypertensive dosage, especially for drugs that are excreted through the kidneys, is necessary to achieve therapeutic effectiveness and minimize the incidence of toxicity. This study aims to determine patient characteristics, drug use patterns, and appropriate use of antihypertensive doses. Observational research method with retrospective data collection based on outpatient medical records in January-December 2023 using purposive sampling. Of the total 14 patients, most patients were male (58.82%). Most patients were in the early elderly category (46-55 years) (50%). Based on the diagnosis of the disease with the highest percentage, stage 5 chronic kidney disease as the main diagnosis (100%), congestive heart failure as a secondary diagnosis (21.42%), hypertension as a comorbidity (57.14%), and anemia as a complication (100%). The monotherapy antihypertensive drug that is widely used is furosemide (64.28%). Meanwhile, the combination of antihypertensive drugs used was furosemide + telmisartan (7.14%). Evaluation of antihypertensive drugs use obtained 100% according to the dose.
References
Ariyanto, Hadisaputro, S., Lestariningsih., Adi, S., Budijitno, S. Beberapa Faktor Risiko Kejadian Penyakit Ginjal Kronik (PGK) Tahap V pada Kelompok Usia Kurang dari 50 Tahun (Studi di RSUD dr.H.Soewondo Kendal dan RSUD dr.Adhyatma,MPH Semarang). Jurnal Epidemiologin Kesehatan Komunitas 2018, 3(1), 1 – 6.
Putri, E., Alini, Indrawati. Hubungan Dukungan Keluarga dan Kebutuhan Spiritual Dengan Tingkat Kecemasan Pasien Gagal Ginjal Kronik Dalam Menjalani Terapi Hemodialisis di Rsud Bangkinang. Jurnal Ners 2020, 4(2), 47 – 55.
Riskesdas. Laporan Hasil Riset Kesehatan Dasar Indonesia Tahun 2018. Jakarta: Departemen Kesehatan RI 2018.
Indonesia Renal Registry (IRR). Report of Indonesian Renal Registry, 9th Edition. Jakarta: Perkumpulan Nefrologi Indonesia (Pernefri) 2018.
Nurbadriyah, W, D. Asuhan Keperawatan Penyakit Ginjal Kronis dengan Pendekatan 3s (1st ed.). Literasi Nusantara 2021.
Bikbov, B., Purcell, C.A., Levey, A.S., Smith, M., Abdoli, A., Abebe, M., Adebayo, O.M., Afarideh, M., Agarwal, S.K., Agudelo-Botero, M. and Ahmadian, E. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet 2020, 395(10225), 709–733.
Susantri, W., Woferst, R. Hubungan Kepatuhan Menjalani Terapi Hemodialisis dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik di Masa Pandemi Covid-19. Journal of Holistic Nursing and Health Science 2022, 5(2), 216–225.
Liu, M.W.C., Syukri, M., Abdullah, A., Chien, L.Y. Missing in-center hemodialysis sessions among patients with end stage renal disease in Banda Aceh, Indonesia. International Journal of Environmental Research and Public Health 2021, 18(17), 9215.
Sinha, A.D., Agarwal, R. Clinical pharmacology of antihypertensive therapy for the treatment of hypertension in CKD. Clinical Journal of the American Society of Nephrology 2019, 14(5), 757–764.
Nissenson, A,R., Fine, R,N. Handbook of Dialysis Therapy 5th Edition. Canada: Elsevier 2017.
Dhrik, M., Prasetya, A.P.R. Kajian Pemilihan Obat Antihipertensi Pada Penderita Hipertensi Dengan gagal Ginjal Kronis yang Menjalani Hemodialisis. Acta Holist. Pharm 2019, 2(1), 18-26.
Maria, N., Susilo, F.V., Simarmata, M. Drug Selection, Dosage Adjustment, and Potential Interaction of Antihypertensive and Antidiabetic for Chronic Kidney Disease with Hemodialysis. Jurnal Ilmu Kefarmasian Indonesia 2023, 21(2), 254.
Afifah, F., Amal, S. Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Rawat Jalan GGK dengan Hemodialisa di RSUP dr. Soeradji Tirtonegoro Klaten Tahun 2017. Pharmaceutical Journal of Islamic Pharmacy 2019, 3(2), 21-27.
Husna, N., Larasati, N. Evaluasi Penggunaan Terapi Antihipertensi Pada Pasien Gagal Ginjal Kronik Dengan Hemodialisis. Media Ilmu Kesehatan 2019, 8(1), 1–8.
Rachmah, D.N. Regulasi Diri Dalam Belajar Pada Mahasiswa Yang Memiliki Peran Banyak. Jurnal psikologi 2015, 42(1), 61-77
Auliafendri, N., Khairat, R. Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Ginjal Kronik (Ggk) di Unit Hemodialisa Rsu Imelda Pekerja Indonesia Medan. JIFI 2022, 6(1), 22-29.
Pradiningsih, A., Nopitasari, B. L., Furqani, N., Wahyuningsih, E. Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Gagal Ginjal Kronik Rawat Inap Di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat. Jurnal ilmu kefarmasian 2020, 1(2), 61-65.
Suari, L.G.S.A., I Gede Yasa Asmara, Ida Ayu Eka Widiastuti. Karakteristik Hipertensi pada Pasien PGTA yang Menjalani Hemodialisis di RSUD Provinsi NTB Tahun 2021. Lombok Medical Journal 2022, 1(2), 94–99.
Utomo, E.K., Rochmawati, E. Gambaran Tekanan Darah Dan Hemoglobin Pasien Gagal Ginjal Yang Menjalani Terapi Hemodialisis. Jurnal Keperawatan Duta Medika 2021, 1(1), 17–21.
Jairoun, A.A., Ping, C.C., Ibrahim, B. Predictors of chronic kidney disease survival in type 2 diabetes: a 12-year retrospective cohort study utilizing estimated glomerular filtration rate. Scientific Reports 2024, 14(1), 1–13.
Maharani, M. P., Kurniati, I., Sidharti, L. Kejadian Gagal Ginjal Kronik pada Pasien Diabetes Melitus Tipe 2 Medula. Medical Profession Journal of Lampung 2024, 14(2), 315–320.
Kumar, M., Dev, S., Khalid, M.U., Siddenthi, S.M., Noman, M., John, C., Akubuiro, C., Haider, A., Rani, R., Kashif, M., Varrassi, G., Khatri, M., Kumar, S., Mohamad, T. The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management. Cureus 2023, 15(9), 1-13.
Arici, M. Management of Chronic Kidney Disease 2nd Edition. Switzerland: Springer 2023.
Rifai, N., Chiu, R.W.K., Young, I., Burnham, C.-A.D., Wittwer, C.T. Tietz Textbook of Laboratory Medicine, 7th ed. Missouri: Else-vier 2023.
Vanmeter, K,C., Huber, R, J. Gould’s Pathophysiology for the Health Professions 7th Edition. Missouri: Elsevier 2023.
Bhatti, N.K., Karimi Galougahi, K., Paz, Y., Nazif, T., Moses, J.W., Leon, M.B., Stone, G.W., Kirtane, A.J., Karmpaliotis, D., Bokhari, S. Hardy, M.A. Diagnosis and Management of Cardiovascular Disease in Advanced and End-Stage Renal Disease. Journal of the American Heart Association 2016, 5(8), e003648.
Yusman, F.A., Dewi, R.T.K., Mashuri, Y.A., Nurhayatun, E. and Giani, M.T. Faktor Yang Berkaitan Dengan Kejadian Asites Pada Pasien Penyakit Ginjal Kronik Yang Menjalani Hemodialisis Di RSUD Dr Moewardi Surakarta: Sebuah Studi Potong Lintang. Jurnal Penyakit Dalam Indonesia 2020, 7(3), 154.
Artiany, S., Gamayana, Y., Aji, T. Gambaran Komorbid pada Pasien Hemodialisis di Rumah Sakit Angkatan Udara (RSAU) dr Esnawan Antariksa. Jurnal Keperawatan Cikini 2021, 2(2), 1–6.
Hamrahian, S. M., Vilayet, S., Herberth, J., Fülöp, T. Prevention of Intradialytic Hypotension in Hemodialysis Patients: Current Chal-lenges and Future Prospects. International Journal of Nephrology and Renovascular Disease 2023, 173–181.
Flythe, J.E., Assimon, M.M., Tugman, M.J., Narendra, J.H., Singh, S.K., Jin, W., Li, Q., Bansal, N., Hostetter, T.H., Dember, L.M. Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study. Kidney International Reports 2022, 7(10), 2186–95.
Chen, W., Wang, F., Zhao, Y., Zhang, L., Chen, Z., Dai, M. Efficacy and Safety of Furosemide for Prevention of Intradialytic Hypoten-sion in Haemodialysis Patients: Protocol for a Multicentre Randomised Controlled Trial. BMJ Open 2021, 11(7), e048015.
Wang, J.G., Palmer, B.F., Vogel Anderson, K., Sever, P. Amlodipine in the current management of hypertension. J Clin Hypertens 2023, 25(9), 801–807.
Paranoan, R., Manggau, M.A., Kasim, H., Djide, M, N., Lallo, S., Djabir, Y.Y. Analisis efektivitas dan efek samping penggunaan anti-hipertensi pada pasien gagal ginjal kronik rawat inap di RSUP Dr. Wahidin Sudirohusodo. Majalah Farmasi dan Farmakologi 2019, 23(1), 13-15.
Samir, A., Aboel-Naga, S., Shehata, A., Abdelhamid, M. Telmisartan versus Enalapril In heart failure with reduced ejection fraction patients with Moderately impaired kidney Functions; randomized controlled trial: “TRIUMF trial”. The Egyptian Heart Journal 2023, 75(1), 68.
Adenwalla, S.F., Hull, K.L., Graham-Brown, M.P.M. What to do with foundation therapies for heart failure for patients with end-stage kidney disease on haemodialysis. British Journal of Hospital Medicine 2024, 85(4), 1– 10.
Dezsi, C,A. The Different Therapeutic Choices with ARBs. Which One to Give? When? Why?. Am J Cardiovasc Drugs 2016, 16, 255–266.
Saritha, M., Kumar, P., Rama Mohan, P. Metrics of clonidine utilization in maintenance hemodialysis patients. International Journal of Basic & Clinical Pharmacology 2019, 8(6), 1229.
Frazier, M,S., Fuqua, T. Essentials of Human Diseases and Conditions, Seventh Edition. Missouri: Elsevier.
Kemenkes RI. 2011. Modul Penggunaan Obat Rasional. Jakarta: Kemenkess RI 2021.
Nasution, A. Farmakokinetika Klinis. Medan: USU Press 2015.
Oh, S,W., Han, S.Y. Loop Diuretics in Clinical Practice. Electrolyte and Blood Pressure 2015, 13(1), 17–21.
Usman, A., Nilsya, D., Zebua, F. Aplikasi Visual Basic.Net Dalam Penentuan Dosis Obat Pasien Hipertensi Komplikasi Gagal Ginjal. Jurnal Saintika 2018, 18(1), 45–49.
Coviv, A., Lerma, E,V., Kanbay, M. Resistant Hypertension in Chronic Kidney Disease. Switzerland: Springer International Publishing AG 2017.
Skorecki, K., Chertow, G,M., Marsden, P.A., Yu, A.S.L., Taal, W.T. Brenner & Rector’s The Kidney 10th Edition. United States of America: Elsevier 2016.
Ulfa, N.M., Ernawati, I., Purwanti, Kurniawanto, R., Indrawati, A. Profil Penggunaan Obat Antianemia, Antihipertensi, dan Antidiabetik pada Pasien Penyakit Ginjal Kronik di Salah Satu Rumah Sakit Wilayah Surabaya Selatan. PHARMACY: Jurnal Farmasi Indonesia 2019, 16(2), 296-306.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Jurnal Riseta Naturafarm

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.